{"id":10177,"date":"2024-05-24T22:37:23","date_gmt":"2024-05-24T20:37:23","guid":{"rendered":"https:\/\/www.astrodose.eu\/?p=10177"},"modified":"2024-05-24T22:38:38","modified_gmt":"2024-05-24T20:38:38","slug":"teadlased-utlevad-et-psilotsubiini-mikrodoosimine-voib-ravida-diabeeti","status":"publish","type":"post","link":"https:\/\/www.astrodose.eu\/et\/science-and-studies\/scientists-say-microdosing-psilocybin-may-treat-diabetes\/","title":{"rendered":"Teadlased \u00fctlevad, et psilots\u00fcbiini mikrodoosimine v\u00f5ib ravida diabeeti"},"content":{"rendered":"

Diabeeti p\u00f5eb praegu 537 miljonit inimest kogu maailmas - ja see arv on ainult kasvamas. Kuna 2045. aastaks prognoositakse, et 783 miljonil inimesel on diabeet, tuleb v\u00e4lja t\u00f6\u00f6tada t\u00f5husamad ja taskukohasemad ravimeetodid. Uus uuring n\u00e4itab, et psilots\u00fcbiini mikrodoosimine v\u00f5ib selles osas kaasa aidata.\u00a0<\/strong><\/p>\n\n\n\n

Viimastel aastatel on psilots\u00fcbiin\u00a0(ps\u00fchhoaktiivne \u00fchend maagilistes seentes ja tr\u00fchvlites)\u00a0<\/em>on hakatud tunnustama selle terapeutilist potentsiaali, eriti vaimse tervise seisundite puhul. Tulemused on nii paljut\u00f5otavad, et n\u00fc\u00fcd uuritakse seda isegi seoses f\u00fc\u00fcsilise valu raviga, mis on andnud h\u00e4id tulemusi. Kuna nii suur osa selle mehhanismidest on endiselt m\u00f5istatus, ei ole ime, et k\u00f5ikide erialade teadlased soovivad innukalt uurida psilots\u00fcbiini edasisi kasutusv\u00f5imalusi.<\/strong><\/p>\n\n\n\n

See kajastub p\u00f5nev uus uuring<\/a>, avaldatud ajakirjas Geenid<\/em>, mis uurib psiilots\u00fcbiini eluj\u00f5ulisust diabeedi raviks. Uuringu autor Igor Kovalchuk selgitas;<\/p>\n\n\n\n

\"Diabeet ja metaboolne s\u00fcndroom vaevavad \u00fchiskonda ja me otsisime erinevaid v\u00f5imalusi, kuidas aidata kaasa v\u00f5itlusele nende haiguste vastu... Kuna mikrodooside manustamine seentega v\u00f5ib saada \u00fcheks raviv\u00f5imaluseks erinevate haiguste puhul, tahtsime testida, kas selle toimeaine, psiilots\u00fcbiin, m\u00f5jub ka diabeedivastaselt.\"<\/em><\/p>\n\n\n\n

\"\"<\/figure>\n\n\n\n

Psilots\u00fcbiin: Serotoniini sosistaja<\/h2>\n\n\n\n

Ja see ei ole kindlasti mitte ainult ps\u00fchhedeelne b\u00e4ndi h\u00fcppamine. Psilots\u00fcbiin suhtleb aju serotoniiniretseptoritega, mis on \u00fcks paljudest viisidest, kuidas see on efektiivne kui vaimse tervise ravi<\/a>. Kuid kas teadsite, et meil on serotoniini retseptorid ka k\u00f5hun\u00e4\u00e4rmes, kus toodetakse insuliini? Insuliini tootmisel\u00a0(v\u00f5i selle puudumine)\u00a0<\/em>olles diabeedi p\u00f5hjuste keskmes, kas psilots\u00fcbiini unikaalne oskuste kogum v\u00f5iks muuta m\u00e4ngu?<\/p>\n\n\n\n

Mis p\u00f5hjustab diabeeti?<\/h3>\n\n\n\n

Diabeet on krooniline ainevahetush\u00e4ire, mis tekib siis, kui k\u00f5hun\u00e4\u00e4re ei suuda enam insuliini toota v\u00f5i kui organism ei suuda toodetud insuliini enam t\u00f5husalt kasutada. Insuliin on hormoon, mis muudab s\u00f6\u00f6dud toidu gl\u00fckoosi energiaks, mida rakud saavad kasutada. Kui meie keha ei suuda insuliini t\u00f5husalt toota v\u00f5i kasutada, p\u00f5hjustab see k\u00f5rge gl\u00fckoosisisalduse veres, mida nimetatakse h\u00fcpergl\u00fckeemia. <\/em>Aja jooksul v\u00f5ib see k\u00f5rge veresuhkru tase kahjustada organismi ning p\u00f5hjustada erinevate organite ja kudede rikkeid. Seega v\u00f5ib psiilots\u00fcbiin uuringu autorite s\u00f5nul pankrease serotoniinirakkudega suheldes takistada elut\u00e4htsate insuliini tootvate rakkude kadumist. <\/p>\n\n\n\n

\"\"
Foto: Matt C on Unsplash<\/mark><\/em><\/figcaption><\/figure>\n\n\n\n

Kuidas uuring toimis<\/h4>\n\n\n\n

Uuringus uurisid teadlased psiilots\u00fcbiini m\u00f5ju pankrease \u03b2-rakkudele. Pankrease \u03b2-rakud on rakud, mis vastutavad insuliini tootmise eest. Kui need on kahjustatud, n\u00e4iteks diabeetiku puhul, on organismi v\u00f5ime reguleerida veresuhkru taset h\u00e4iritud. <\/p>\n\n\n\n

Teadlased eksponeerisid k\u00f5hun\u00e4\u00e4rme \u03b2-rakke k\u00f5rge gl\u00fckoosi- ja lipiidisisaldusega (rasva) <\/em>seisund, mis peegeldab diabeedi p\u00f5hjustatud ainevahetusstressi. Nad kasutasid roti insulinoomi rakuliin<\/a>, teaduslik mudel, mida kasutatakse selle asjakohasuse t\u00f5ttu inimese \u03b2-rakkude funktsiooni suhtes. <\/p>\n\n\n\n

P\u00e4rast kasvatamist toitaineterikkas keskkonnas t\u00f6\u00f6deldi osa rakke konkreetse psiilots\u00fcbiini kontsentratsiooniga. P\u00e4rast psiilots\u00fcbiiniga t\u00f6\u00f6tlemist kasteti rakud k\u00f5rge gl\u00fckoosi- ja lipiidisisaldusega tingimustesse, mis on arvutatud nii, et tekitada diabeetikute k\u00f5hun\u00e4\u00e4rme \u03b2-rakkudes \u00fcldiselt t\u00e4heldatud koormust ja kahjustusi. <\/p>\n\n\n\n

\"\"
Foto: Julia Koblitz on Unsplash<\/mark><\/em><\/figcaption><\/figure>\n\n\n\n

Psilots\u00fcbiin kaitseb rakke<\/h3>\n\n\n\n

Teadlased t\u00e4heldasid, et psiilots\u00fcbiiniga t\u00f6\u00f6deldud rakud n\u00e4itasid oluliselt paremat eluj\u00f5ulisust v\u00f5rreldes nendega, mida psiilots\u00fcbiiniga ei ravitud. See leid viitab sellele, et psiilots\u00fcbiinil on k\u00f5hun\u00e4\u00e4rme \u03b2-rakkudele kaitsev m\u00f5ju, mis aitab leevendada diabeediga seotud ainevahetusstressi kahjustusi. <\/p>\n\n\n\n

Edasisel anal\u00fc\u00fcsil suutsid teadlased selgitada, miks psilots\u00fcbiinil v\u00f5ib olla selline kaitsev m\u00f5ju. Kasutades 'Western Blot<\/a>' anal\u00fc\u00fcsis leiti, et psiilots\u00fcbiiniravi viis mitme olulise apoptootilise biomarkeri v\u00e4henemiseni \u03b2-rakkudes, mis olid kokku puutunud k\u00f5rge gl\u00fckoosi- ja lipiidisisaldusega, mis imiteerib diabeeti. Apoptoos<\/a> (mis t\u00e4hendab programmeeritud rakusurma) <\/em>m\u00e4ngib v\u00f5tmerolli \u03b2-rakkude kadumisel diabeedi korral. Psiilots\u00fcbiini t\u00e4heldatud v\u00f5ime v\u00e4hendada selle protsessiga seotud markereid t\u00f5stab esile selle potentsiaali \u03b2-rakkude p\u00e4\u00e4stmiseks diabeetiliste seisundite korral. <\/p>\n\n\n\n

Vastuseks oma meeskonna p\u00f5nevatele tulemustele m\u00e4rkis Kovalchuk;<\/p>\n\n\n\n

\"Me ei oodanud, et psiilots\u00fcbiin m\u00f5jub k\u00f5hun\u00e4\u00e4rme rakkudele nii h\u00e4sti,\" <\/em><\/p>\n\n\n\n

Ta \u00fctles ka PsyPostile, et;<\/p>\n\n\n\n

\"...maagiliste seente mikrodoosimisel on t\u00f5en\u00e4oliselt positiivne m\u00f5ju metaboolse s\u00fcndroomi (diabeedieelne) ja diabeediga inimestele,\"<\/em><\/p>\n\n\n\n

Uuringu piirangud: Varajased p\u00e4evad<\/h4>\n\n\n\n

Kuigi see on paljulubav algus selles uurimisvaldkonnas, on uuringus piiranguid, mis viitavad vajadusele edasiste uurimisprojektide j\u00e4rele. K\u00f5ige olulisem oli muidugi see, et uuring viidi l\u00e4bi roti insulinoomi rakuliini abil, mis on k\u00fcll sobiv v\u00e4ga varajaste uuringute jaoks, kuid ei suuda t\u00e4ielikult j\u00e4ljendada elusorganismi keerukust. <\/p>\n\n\n\n

Kovaluchuk m\u00e4rkis; \"Me peame selle uuringu l\u00e4bi viima loomadel, et olla kindel, et see toimib sama h\u00e4sti kui in vitro.\" <\/em><\/p>\n\n\n\n

Lisaks vaadeldi selles uuringus psiilots\u00fcbiini m\u00f5ju ainult spetsiifilistes stressitingimustes, mis olid p\u00f5hjustatud k\u00f5rge gl\u00fckoosisisalduse ja k\u00f5rge lipiidisisaldusega tingimustes. See kujutab endast ainult \u00fchte aspekti diabeedist, mis on multifaktoorne haigus, mis t\u00e4hendab, et sellel on mitmesuguseid patoloogiaid, sealhulgas p\u00f5letik, insuliiniresistentsus ja 1. t\u00fc\u00fcpi diabeedi puhul autoimmuunsed komponendid.<\/p>\n\n\n\n

\"\"<\/figure>\n\n\n\n

Revolutsioon diabeedi ravis<\/h3>\n\n\n\n

Selle uuringu keskmes on potentsiaalne revolutsioon diabeedi ravis. See on oluline, sest tegemist on haigusega, mida tuleb hallata kogu inimese elu jooksul. Paljudes riikides on diabeetiku tervise s\u00e4ilitamiseks vajalikud ravimid kallid ja madalama sissetulekuga inimeste puhul ohverdatakse need sageli toidu v\u00f5i \u00fc\u00fcri asemel. Nagu Kolvachuk \u00fctleb \"Me otsime alati rohkem looduslikke\/traditsioonilisi\/holistilisi viise haiguste ravimiseks.\"<\/em><\/p>\n\n\n\n

Kas see uuring v\u00f5ib sillutada teed tulevikku, kus inimesed saavad oma tervist hallata taskukohase ja looduslikult esineva maagilise tr\u00fchvli abil?<\/strong><\/p>\n\n\n\n

Loodame! <\/strong>\ud83e\udd1e<\/p>\n\n\n\n

M\u00e4rkus: Kui olete diabeetik, \u00e4rge l\u00f5petage oma ravimite v\u00f5tmist! See uuring, kuigi p\u00f5nev, on alles algusj\u00e4rgus. Enne elustiili muutmist pidage alati n\u00f5u oma arstiga.<\/em><\/p>","protected":false},"excerpt":{"rendered":"

Diabetes is a condition that currently affects 537 million people globally \u2014 and that number is only rising. With a prospective 783 million people on course to have diabetes by 2045, more effective and affordable treatments must be developed. A new study suggests microdosing psilocybin could play a part.\u00a0 In recent years,\u00a0psilocybin\u00a0(the psychoactive compound in […]<\/p>\n","protected":false},"author":11,"featured_media":10180,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[35],"tags":[],"class_list":["post-10177","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-science-and-studies"],"yoast_head":"\nScientists Say Microdosing Psilocybin May Treat Diabetes<\/title>\n<meta name=\"description\" content=\"It's an illness that affects 537 million people globally, but a new hope has emerged, scientists say microdosing psilocybin may treat diabetes.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.astrodose.eu\/et\/teadus-ja-uuringud\/teadlased-utlevad-et-psilotsubiini-mikrodoosimine-voib-ravida-diabeeti\/\" \/>\n<meta property=\"og:locale\" content=\"et_EE\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Scientists Say Microdosing Psilocybin May Treat Diabetes\" \/>\n<meta property=\"og:description\" content=\"It's an illness that affects 537 million people globally, but a new hope has emerged, scientists say microdosing psilocybin may treat diabetes.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.astrodose.eu\/et\/teadus-ja-uuringud\/teadlased-utlevad-et-psilotsubiini-mikrodoosimine-voib-ravida-diabeeti\/\" \/>\n<meta property=\"og:site_name\" content=\"Astrodose - 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