{"id":10177,"date":"2024-05-24T22:37:23","date_gmt":"2024-05-24T20:37:23","guid":{"rendered":"https:\/\/www.astrodose.eu\/?p=10177"},"modified":"2024-05-24T22:38:38","modified_gmt":"2024-05-24T20:38:38","slug":"a-tudosok-szerint-a-pszilocibin-mikrodozisa-cukorbetegseget-kezelhet","status":"publish","type":"post","link":"https:\/\/www.astrodose.eu\/hu\/science-and-studies\/scientists-say-microdosing-psilocybin-may-treat-diabetes\/","title":{"rendered":"A tud\u00f3sok szerint a Psilocybin mikrod\u00f3zisa kezelheti a cukorbetegs\u00e9get"},"content":{"rendered":"

A cukorbetegs\u00e9g jelenleg 537 milli\u00f3 embert \u00e9rint vil\u00e1gszerte - \u00e9s ez a sz\u00e1m csak n\u00f6vekszik. Mivel 2045-re v\u00e1rhat\u00f3an 783 milli\u00f3 ember lesz cukorbeteg, hat\u00e9konyabb \u00e9s megfizethet\u0151bb kezel\u00e9seket kell kidolgozni. Egy \u00faj tanulm\u00e1ny szerint a pszilocibin mikrod\u00f3zisa szerepet j\u00e1tszhat ebben.\u00a0<\/strong><\/p>\n\n\n\n

Az ut\u00f3bbi \u00e9vekben a pszilocibin\u00a0(a var\u00e1zsgomb\u00e1ban \u00e9s a szarvasgomb\u00e1ban tal\u00e1lhat\u00f3 pszichoakt\u00edv vegy\u00fclet)\u00a0<\/em>kezdt\u00e9k felismerni ter\u00e1pi\u00e1s potenci\u00e1lj\u00e1t, k\u00fcl\u00f6n\u00f6sen a ment\u00e1lis eg\u00e9szs\u00e9gi \u00e1llapotok eset\u00e9ben. Az eredm\u00e9nyek annyira \u00edg\u00e9retesek, hogy most m\u00e1r a fizikai f\u00e1jdalom kezel\u00e9s\u00e9vel kapcsolatban is vizsg\u00e1lj\u00e1k, sikeres eredm\u00e9nyekkel. Mivel mechanizmusainak nagy r\u00e9sze m\u00e9g mindig rejt\u00e9ly, nem csoda, hogy a tud\u00f3sok minden tudom\u00e1ny\u00e1gban lelkesen kutatj\u00e1k a pszilocibin tov\u00e1bbi felhaszn\u00e1l\u00e1si lehet\u0151s\u00e9geit.<\/strong><\/p>\n\n\n\n

Ezt t\u00fckr\u00f6zi egy izgalmas \u00faj tanulm\u00e1ny<\/a>, megjelent a Journal G\u00e9nek<\/em>, amely a pszilocibin \u00e9letk\u00e9pess\u00e9g\u00e9t vizsg\u00e1lja a cukorbetegs\u00e9g kezel\u00e9s\u00e9ben. A tanulm\u00e1ny szerz\u0151je, Igor Kovalchuk kifejtette;<\/p>\n\n\n\n

\"A cukorbetegs\u00e9g \u00e9s a metabolikus szindr\u00f3ma s\u00fajtja a t\u00e1rsadalmat, \u00e9s mi k\u00fcl\u00f6nb\u00f6z\u0151 m\u00f3dokat kerest\u00fcnk arra, hogy hozz\u00e1j\u00e1ruljunk az eml\u00edtett \u00e1llapotok elleni k\u00fczdelemhez... Mivel a gomb\u00e1k mikrod\u00f3zisa a k\u00fcl\u00f6nb\u00f6z\u0151 betegs\u00e9gek egyik kezel\u00e9si lehet\u0151s\u00e9ge lehet, meg akartuk vizsg\u00e1lni, hogy a hat\u00f3anyag\u00e1nak, a pszilocibinnek van-e cukorbetegs\u00e9g-ellenes hat\u00e1sa is.\".<\/em><\/p>\n\n\n\n

\"\"<\/figure>\n\n\n\n

Pszilocibin: A szerotonin suttog\u00f3<\/h2>\n\n\n\n

\u00c9s ez hat\u00e1rozottan nem csak pszichedelikus sz\u00e1guldoz\u00e1s. A pszilocibin k\u00f6lcs\u00f6nhat\u00e1sba l\u00e9p az agy szerotonin receptoraival, ami egyike a sz\u00e1mos m\u00f3dnak, ahogyan hat\u00e1sos, mint egy ment\u00e1lis eg\u00e9szs\u00e9g\u00fcgyi kezel\u00e9s<\/a>. Tudta azonban, hogy a hasny\u00e1lmirigy\u00fcnkben is vannak szerotonin receptoraink, ahol az inzulin termel\u0151dik? Az inzulintermel\u00e9ssel\u00a0(vagy annak hi\u00e1nya)\u00a0<\/em>mivel a cukorbetegs\u00e9g kiv\u00e1lt\u00f3 okainak k\u00f6z\u00e9ppontj\u00e1ban \u00e1ll, a pszilocibin egyed\u00fcl\u00e1ll\u00f3 k\u00e9pess\u00e9gei megv\u00e1ltoztathatj\u00e1k a j\u00e1t\u00e9kot?<\/p>\n\n\n\n

Mi okozza a cukorbetegs\u00e9get?<\/h3>\n\n\n\n

A cukorbetegs\u00e9g kr\u00f3nikus anyagcserezavar, amely akkor l\u00e9p fel, amikor a hasny\u00e1lmirigy nem k\u00e9pes inzulint termelni, vagy a szervezet nem tudja hat\u00e9konyan felhaszn\u00e1lni a termelt inzulint. Az inzulin az a hormon, amely az elfogyasztott t\u00e1pl\u00e1l\u00e9kb\u00f3l sz\u00e1rmaz\u00f3 gl\u00fck\u00f3zt a sejtek \u00e1ltal felhaszn\u00e1lhat\u00f3 energi\u00e1v\u00e1 alak\u00edtja. Ha a szervezet\u00fcnk nem k\u00e9pes hat\u00e9konyan inzulint termelni vagy felhaszn\u00e1lni, az a v\u00e9r magas gl\u00fck\u00f3zszintj\u00e9hez vezet, amit \u00fagy h\u00edvunk, hogy hiperglik\u00e9mia. <\/em>Id\u0151vel ezek a magas v\u00e9rcukorszintek k\u00e1ros\u00edthatj\u00e1k a szervezetet, \u00e9s k\u00fcl\u00f6nb\u00f6z\u0151 szervek \u00e9s sz\u00f6vetek meghib\u00e1sod\u00e1s\u00e1t okozhatj\u00e1k. A tanulm\u00e1ny szerz\u0151i szerint teh\u00e1t a pszilocibin a hasny\u00e1lmirigy szerotoninsejtjeivel k\u00f6lcs\u00f6nhat\u00e1sba l\u00e9pve k\u00e9pes lehet megakad\u00e1lyozni a l\u00e9tfontoss\u00e1g\u00fa inzulintermel\u0151 sejtek elveszt\u00e9s\u00e9t. <\/p>\n\n\n\n

\"\"
Matt C fot\u00f3ja az Unsplash-en<\/mark><\/em><\/figcaption><\/figure>\n\n\n\n

Hogyan m\u0171k\u00f6d\u00f6tt a tanulm\u00e1ny<\/h4>\n\n\n\n

A tanulm\u00e1nyban a kutat\u00f3k a pszilocibin hasny\u00e1lmirigy \u03b2-sejtekre gyakorolt hat\u00e1s\u00e1t vizsg\u00e1lt\u00e1k. A hasny\u00e1lmirigy \u03b2-sejtjei az inzulintermel\u00e9s\u00e9rt felel\u0151s sejtek. Ha ezek k\u00e1rosodnak, p\u00e9ld\u00e1ul egy cukorbeteg embern\u00e9l, a szervezet v\u00e9rcukorszint-szab\u00e1lyoz\u00f3 k\u00e9pess\u00e9ge megzavarodik. <\/p>\n\n\n\n

A kutat\u00f3k a hasny\u00e1lmirigy \u03b2-sejtjeit magas gl\u00fck\u00f3z- \u00e9s lipidszintnek tett\u00e9k ki. (k\u00f6v\u00e9r) <\/em>\u00e1llapotok, amely a cukorbetegs\u00e9g okozta anyagcsere-stresszt t\u00fckr\u00f6zi. A vizsg\u00e1lathoz egy patk\u00e1ny inzulin\u00f3ma sejtvonal<\/a>tudom\u00e1nyos modell, amelyet a hum\u00e1n \u03b2-sejtek m\u0171k\u00f6d\u00e9s\u00e9re vonatkoz\u00f3 relevanci\u00e1ja miatt haszn\u00e1lnak. <\/p>\n\n\n\n

Miut\u00e1n t\u00e1panyagban gazdag t\u00e1ptalajban teny\u00e9sztett\u00e9k \u0151ket, a sejtek egy r\u00e9sz\u00e9t meghat\u00e1rozott pszilocibin-koncentr\u00e1ci\u00f3val kezelt\u00e9k. A pszilocibines kezel\u00e9s ut\u00e1n a sejteket magas gl\u00fck\u00f3z- \u00e9s lipidtartalm\u00fa k\u00f6r\u00fclm\u00e9nyek k\u00f6z\u00e9 mer\u00edtett\u00e9k, amelyek a cukorbetegek hasny\u00e1lmirigy \u03b2-sejtjeiben \u00e1ltal\u00e1nosan megfigyelhet\u0151 megterhel\u00e9s \u00e9s k\u00e1rosod\u00e1s kiv\u00e1lt\u00e1s\u00e1ra lettek kisz\u00e1m\u00edtva. <\/p>\n\n\n\n

\"\"
Fot\u00f3: Julia Koblitz on Unsplash<\/mark><\/em><\/figcaption><\/figure>\n\n\n\n

A psilocybin v\u00e9di a sejteket<\/h3>\n\n\n\n

A kutat\u00f3k megfigyelt\u00e9k, hogy a pszilocibinnel kezelt sejtek jelent\u0151sen jobb \u00e9letk\u00e9pess\u00e9get mutattak azokhoz k\u00e9pest, amelyeket nem kezeltek pszilocibinnel. Ez a meg\u00e1llap\u00edt\u00e1s arra utal, hogy a pszilocibin v\u00e9d\u0151 hat\u00e1ssal van a hasny\u00e1lmirigy \u03b2-sejtjeire, ami seg\u00edt enyh\u00edteni a cukorbetegs\u00e9ggel j\u00e1r\u00f3 anyagcsere-stressz okozta k\u00e1rokat. <\/p>\n\n\n\n

A tov\u00e1bbi elemz\u00e9s sor\u00e1n a kutat\u00f3k bepillant\u00e1st nyertek abba, hogy a pszilocibin mi\u00e9rt fejtheti ki ezeket a v\u00e9d\u0151hat\u00e1sokat. A 'Western Blot<\/a>' elemz\u00e9se sor\u00e1n a tanulm\u00e1ny meg\u00e1llap\u00edtotta, hogy a pszilocibin kezel\u00e9s sz\u00e1mos kulcsfontoss\u00e1g\u00fa apoptotikus biomarker cs\u00f6kken\u00e9s\u00e9hez vezetett a \u03b2-sejtekben, amelyek a cukorbetegs\u00e9get imit\u00e1l\u00f3 magas gl\u00fck\u00f3z- \u00e9s magas lipidszintnek voltak kit\u00e9ve. Apopt\u00f3zis<\/a> (ami programozott sejthal\u00e1lt jelent) <\/em>kulcsszerepet j\u00e1tszik a cukorbetegs\u00e9gben a \u03b2-sejtek elveszt\u00e9s\u00e9ben. A pszilocibin megfigyelt k\u00e9pess\u00e9ge, hogy cs\u00f6kkenti az ezzel a folyamattal \u00f6sszef\u00fcgg\u0151 markereket, kiemeli annak lehet\u0151s\u00e9g\u00e9t, hogy cukorbetegs\u00e9gben megmentse a \u03b2-sejteket. <\/p>\n\n\n\n

Csapata izgalmas eredm\u00e9nyeire reag\u00e1lva Kovalcsuk megjegyezte;<\/p>\n\n\n\n

\"Nem sz\u00e1m\u00edtottunk arra, hogy a pszilocibin ilyen j\u00f3l hat a hasny\u00e1lmirigy sejtekre.\" <\/em><\/p>\n\n\n\n

Azt is elmondta a PsyPostnak, hogy;<\/p>\n\n\n\n

\"...a var\u00e1zsgomb\u00e1k mikrod\u00f3zisa val\u00f3sz\u00edn\u0171leg pozit\u00edv hat\u00e1ssal lesz a metabolikus szindr\u00f3m\u00e1ban (pre-diab\u00e9tesz) \u00e9s cukorbetegs\u00e9gben szenved\u0151kre.\"<\/em><\/p>\n\n\n\n

A vizsg\u00e1lat korl\u00e1tai: Korai napok<\/h4>\n\n\n\n

B\u00e1r a kutat\u00e1s \u00edg\u00e9retes kezdet ezen a kutat\u00e1si ter\u00fcleten, a tanulm\u00e1nynak vannak olyan korl\u00e1tai, amelyek tov\u00e1bbi kutat\u00e1si projektek sz\u00fcks\u00e9gess\u00e9g\u00e9t jelzik. A legfontosabb term\u00e9szetesen az, hogy a vizsg\u00e1latot patk\u00e1ny inzulin\u00f3ma sejtvonallal v\u00e9gezt\u00e9k, amely b\u00e1r alkalmas a nagyon korai vizsg\u00e1latokra, nem k\u00e9pes teljes m\u00e9rt\u00e9kben reproduk\u00e1lni az \u00e9l\u0151 szervezet komplexit\u00e1s\u00e1t. <\/p>\n\n\n\n

Kovaluchuk megjegyezte; \"Ezt a vizsg\u00e1latot \u00e1llatokon kell elv\u00e9gezn\u00fcnk, hogy biztosak lehess\u00fcnk abban, hogy ugyanolyan j\u00f3l m\u0171k\u00f6dik, mint in vitro\" - mondta. <\/em><\/p>\n\n\n\n

Ezenk\u00edv\u00fcl ez a tanulm\u00e1ny csak a pszilocibin hat\u00e1sait vizsg\u00e1lta a magas gl\u00fck\u00f3z- \u00e9s magas lipidszint\u0171 stressz \u00e1ltal kiv\u00e1ltott speci\u00e1lis stresszk\u00f6r\u00fclm\u00e9nyek k\u00f6z\u00f6tt. Ez csak egy aspektus\u00e1t k\u00e9pviseli a cukorbetegs\u00e9gnek, amely egy multifaktori\u00e1lis betegs\u00e9g, ami azt jelenti, hogy a patol\u00f3gi\u00e1k sz\u00e9les sk\u00e1l\u00e1j\u00e1t mutatja, bele\u00e9rtve a gyullad\u00e1st, az inzulinrezisztenci\u00e1t \u00e9s az 1-es t\u00edpus\u00fa cukorbetegs\u00e9g eset\u00e9ben az autoimmun komponenseket.<\/p>\n\n\n\n

\"\"<\/figure>\n\n\n\n

Forradalom a cukorbetegs\u00e9g kezel\u00e9s\u00e9ben<\/h3>\n\n\n\n

A tanulm\u00e1ny l\u00e9nyege, hogy a cukorbetegs\u00e9g kezel\u00e9s\u00e9nek lehets\u00e9ges forradalma fel\u00e9 mutat. Ez az\u00e9rt l\u00e9nyeges, mert ez egy olyan \u00e1llapot, amelyet az ember eg\u00e9sz \u00e9lete sor\u00e1n kezelni kell. Sok orsz\u00e1gban a cukorbetegek eg\u00e9szs\u00e9g\u00e9nek meg\u0151rz\u00e9s\u00e9hez sz\u00fcks\u00e9ges gy\u00f3gyszerek dr\u00e1g\u00e1k, \u00e9s az alacsonyabb j\u00f6vedelm\u0171ek eset\u00e9ben gyakran az \u00e9lelmiszer vagy a lakb\u00e9r helyett \u00e1ldozz\u00e1k fel \u0151ket. Ahogy Kolvachuk mondja \"Mindig term\u00e9szetesebb\/hagyom\u00e1nyosabb\/holista m\u00f3dokat keres\u00fcnk a betegs\u00e9gek kezel\u00e9s\u00e9re.\"<\/em><\/p>\n\n\n\n

Lehet, hogy ez a kutat\u00e1s utat nyit egy olyan j\u00f6v\u0151 el\u0151tt, amelyben az emberek a megfizethet\u0151 \u00e9s term\u00e9szetesen el\u0151fordul\u00f3 var\u00e1zsszarvasgomb\u00e1val kezelhetik eg\u00e9szs\u00e9g\u00fcket?<\/strong><\/p>\n\n\n\n

Rem\u00e9lj\u00fck! <\/strong>\ud83e\udd1e<\/p>\n\n\n\n

Megjegyz\u00e9s: Ha cukorbeteg vagy, ne hagyd abba a gy\u00f3gyszered szed\u00e9s\u00e9t! Ez a kutat\u00e1s, b\u00e1r izgalmas, m\u00e9g gyerekcip\u0151ben j\u00e1r. \u00c9letm\u00f3dv\u00e1lt\u00e1s el\u0151tt mindig konzult\u00e1ljon orvos\u00e1val.<\/em><\/p>","protected":false},"excerpt":{"rendered":"

Diabetes is a condition that currently affects 537 million people globally \u2014 and that number is only rising. With a prospective 783 million people on course to have diabetes by 2045, more effective and affordable treatments must be developed. A new study suggests microdosing psilocybin could play a part.\u00a0 In recent years,\u00a0psilocybin\u00a0(the psychoactive compound in […]<\/p>\n","protected":false},"author":11,"featured_media":10180,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[35],"tags":[],"class_list":["post-10177","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-science-and-studies"],"yoast_head":"\nScientists Say Microdosing Psilocybin May Treat Diabetes<\/title>\n<meta name=\"description\" content=\"It's an illness that affects 537 million people globally, but a new hope has emerged, scientists say microdosing psilocybin may treat diabetes.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.astrodose.eu\/hu\/tudomany-es-tanulmanyok\/a-tudosok-szerint-a-pszilocibin-mikrodozisa-cukorbetegseget-kezelhet\/\" \/>\n<meta property=\"og:locale\" content=\"hu_HU\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Scientists Say Microdosing Psilocybin May Treat Diabetes\" \/>\n<meta property=\"og:description\" content=\"It's an illness that affects 537 million people globally, but a new hope has emerged, scientists say microdosing psilocybin may treat diabetes.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.astrodose.eu\/hu\/tudomany-es-tanulmanyok\/a-tudosok-szerint-a-pszilocibin-mikrodozisa-cukorbetegseget-kezelhet\/\" \/>\n<meta property=\"og:site_name\" content=\"Astrodose - 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