{"id":10177,"date":"2024-05-24T22:37:23","date_gmt":"2024-05-24T20:37:23","guid":{"rendered":"https:\/\/www.astrodose.eu\/?p=10177"},"modified":"2024-05-24T22:38:38","modified_gmt":"2024-05-24T20:38:38","slug":"zinatnieki-apgalvo-ka-psilocibina-mikrodozesana-var-arstet-diabetu","status":"publish","type":"post","link":"https:\/\/www.astrodose.eu\/lv\/science-and-studies\/scientists-say-microdosing-psilocybin-may-treat-diabetes\/","title":{"rendered":"Zin\u0101tnieki saka, ka psilocib\u012bna mikrodoz\u0113\u0161ana var \u0101rst\u0113t diab\u0113tu"},"content":{"rendered":"

Diab\u0113ts ir slim\u012bba, ar kuru \u0161obr\u012bd slimo 537 miljoni cilv\u0113ku vis\u0101 pasaul\u0113, un \u0161is skaits tikai pieaug. T\u0101 k\u0101 l\u012bdz 2045. gadam diab\u0113ts var\u0113tu skart 783 miljonus cilv\u0113ku, ir j\u0101izstr\u0101d\u0101 efekt\u012bv\u0101ki un pieejam\u0101ki \u0101rst\u0113\u0161anas veidi. Jaunais p\u0113t\u012bjums liecina, ka psilocib\u012bna mikrodoz\u0113\u0161ana var\u0113tu pal\u012bdz\u0113t.\u00a0<\/strong><\/p>\n\n\n\n

P\u0113d\u0113jos gados psilocib\u012bns\u00a0(psihoakt\u012bvais savienojums burvju s\u0113n\u0113s un trifel\u0113s).\u00a0<\/em>terapeitiskais potenci\u0101ls, jo \u012bpa\u0161i gar\u012bg\u0101s vesel\u012bbas trauc\u0113jumu gad\u012bjum\u0101, ir atz\u012bts. Ieg\u016btie rezult\u0101ti ir tik daudzsolo\u0161i, ka tagad t\u0101 pat tiek p\u0113t\u012bta saist\u012bb\u0101 ar fizisko s\u0101pju \u0101rst\u0113\u0161anu, un rezult\u0101ti ir veiksm\u012bgi. T\u0101 k\u0101 tik daudz no t\u0101 iedarb\u012bbas meh\u0101nismiem joproj\u0101m ir nosl\u0113pums, nav br\u012bnums, ka visu nozaru zin\u0101tnieki labpr\u0101t p\u0113ta psilocib\u012bna izmanto\u0161anas veidus.<\/strong><\/p>\n\n\n\n

Tas atspogu\u013cojas aizraujo\u0161s jauns p\u0113t\u012bjums<\/a>, kas public\u0113ts \u017eurn\u0101l\u0101 G\u0113ni<\/em>, kur\u0101 p\u0113t\u012bta psilocib\u012bna k\u0101 diab\u0113ta \u0101rst\u0113\u0161anas l\u012bdzek\u013ca lietder\u012bba. P\u0113t\u012bjuma autors Igors Kova\u013c\u010duks paskaidroja;<\/p>\n\n\n\n

\"Diab\u0113ts un metaboliskais sindroms nom\u0101c sabiedr\u012bbu, un m\u0113s mekl\u0113j\u0101m da\u017e\u0101dus veidus, k\u0101 veicin\u0101t c\u012b\u0146u pret \u0161\u012bm slim\u012bb\u0101m... T\u0101 k\u0101 mikrodoz\u0113\u0161ana ar s\u0113n\u0113m var\u0113tu k\u013c\u016bt par vienu no da\u017e\u0101du slim\u012bbu \u0101rst\u0113\u0161anas iesp\u0113j\u0101m, m\u0113s v\u0113l\u0113j\u0101mies p\u0101rbaud\u012bt, vai s\u0113\u0146u akt\u012bv\u0101 viela psilocib\u012bns iedarbojas ar\u012b pretdiab\u0113ta virzien\u0101.\"<\/em><\/p>\n\n\n\n

\"\"<\/figure>\n\n\n\n

Psilocib\u012bns: Seroton\u012bna \u0161epin\u0101t\u0101js<\/h2>\n\n\n\n

Un tas noteikti nav tikai psihed\u0113liskais l\u0113ciens pa vi\u013c\u0146iem. Psilocib\u012bns mijiedarbojas ar seroton\u012bna receptoriem smadzen\u0113s, kas ir viens no daudzajiem veidiem, k\u0101 tas ir efekt\u012bvs k\u0101 gar\u012bg\u0101s vesel\u012bbas apr\u016bpe<\/a>. Tom\u0113r vai zin\u0101j\u0101t, ka seroton\u012bna receptori ir ar\u012b aizku\u0146\u0123a dziedzer\u012b, kur veidojas insul\u012bns? Ra\u017eojot insul\u012bnu\u00a0(vai to tr\u016bkums)\u00a0<\/em>t\u0101 k\u0101 psilocib\u012bna unik\u0101lais prasmju kopums var\u0113tu main\u012bt sp\u0113li, jo tas ir diab\u0113ta c\u0113lo\u0146u pamat\u0101?<\/p>\n\n\n\n

Kas izraisa diab\u0113tu?<\/h3>\n\n\n\n

Diab\u0113ts ir hronisks vielmai\u0146as trauc\u0113jums, kas rodas, ja aizku\u0146\u0123a dziedzeris vairs nesp\u0113j ra\u017eot insul\u012bnu vai organisms vairs nesp\u0113j efekt\u012bvi izmantot sara\u017eoto insul\u012bnu. Insul\u012bns ir hormons, kas glikozi no ap\u0113st\u0101s p\u0101rtikas p\u0101rv\u0113r\u0161 ener\u0123ij\u0101, ko var izmantot \u0161\u016bnas. Ja m\u016bsu organisms nesp\u0113j efekt\u012bvi ra\u017eot vai izmantot insul\u012bnu, tas izraisa augstu glikozes l\u012bmeni asin\u012bs, ko sauc par augstu glikozes l\u012bmeni asin\u012bs. hiperglik\u0113mija. <\/em>Laika gait\u0101 \u0161\u0101ds augsts glikozes l\u012bmenis asin\u012bs var boj\u0101t organismu un izrais\u012bt da\u017e\u0101du org\u0101nu un audu mazsp\u0113ju. T\u0101p\u0113c, k\u0101 nor\u0101da p\u0113t\u012bjuma autori, psilocib\u012bns, mijiedarbojoties ar aizku\u0146\u0123a dziedzera seroton\u012bna \u0161\u016bn\u0101m, var nov\u0113rst dz\u012bv\u012bbai svar\u012bgo insul\u012bnu ra\u017eojo\u0161o \u0161\u016bnu zudumu. <\/p>\n\n\n\n

\"\"
Foto - Matt C on Unsplash<\/mark><\/em><\/figcaption><\/figure>\n\n\n\n

K\u0101 tika veikts p\u0113t\u012bjums<\/h4>\n\n\n\n

P\u0113t\u012bjum\u0101 p\u0113tnieki p\u0113t\u012bja psilocib\u012bna ietekmi uz aizku\u0146\u0123a dziedzera \u03b2-\u0161\u016bn\u0101m. Aizku\u0146\u0123a dziedzera \u03b2 \u0161\u016bnas ir \u0161\u016bnas, kas atbild\u012bgas par insul\u012bna ra\u017eo\u0161anu. Ja t\u0101s ir boj\u0101tas, piem\u0113ram, diab\u0113ta gad\u012bjum\u0101, tiek trauc\u0113ta organisma sp\u0113ja regul\u0113t cukura l\u012bmeni asin\u012bs. <\/p>\n\n\n\n

P\u0113tnieki pak\u013c\u0101va aizku\u0146\u0123a dziedzera \u03b2-\u0161\u016bnas augsta glikozes un lip\u012bdu satura (tauki) <\/em>st\u0101voklis, kas atspogu\u013co diab\u0113ta izrais\u012bto metabolisko stresu. Vi\u0146i izmantoja \u017eurku insulinoma \u0161\u016bnu l\u012bnija<\/a>, zin\u0101tniskais modelis, ko izmanto, \u0146emot v\u0113r\u0101 t\u0101 atbilst\u012bbu cilv\u0113ka \u03b2 \u0161\u016bnu funkcijai. <\/p>\n\n\n\n

P\u0113c kultiv\u0113\u0161anas ar bar\u012bbas viel\u0101m bag\u0101t\u0101 barotn\u0113 da\u017eas \u0161\u016bnas tika apstr\u0101d\u0101tas ar noteiktu psilocib\u012bna koncentr\u0101ciju. P\u0113c apstr\u0101des ar psilocib\u012bnu \u0161\u016bnas tika iegremd\u0113tas apst\u0101k\u013cos ar augstu glikozes un lip\u012bdu saturu, kas apr\u0113\u0137in\u0101ti, lai izrais\u012btu spriedzi un boj\u0101jumus, kas parasti nov\u0113roti diab\u0113ta slimnieku aizku\u0146\u0123a dziedzera \u03b2 \u0161\u016bn\u0101s. <\/p>\n\n\n\n

\"\"
Foto - Julia Koblitz on Unsplash<\/mark><\/em><\/figcaption><\/figure>\n\n\n\n

Psilocib\u012bns aizsarg\u0101 \u0161\u016bnas<\/h3>\n\n\n\n

P\u0113tnieki nov\u0113roja, ka \u0161\u016bnas, kas tika apstr\u0101d\u0101tas ar psilocib\u012bnu, uzr\u0101d\u012bja iev\u0113rojami lab\u0101ku dz\u012bvotsp\u0113ju sal\u012bdzin\u0101jum\u0101 ar t\u0101m, kas netika apstr\u0101d\u0101tas ar psilocib\u012bnu. \u0160is atkl\u0101jums liecina, ka psilocib\u012bnam ir aizsarg\u0101jo\u0161a ietekme uz aizku\u0146\u0123a dziedzera \u03b2 \u0161\u016bn\u0101m, kas pal\u012bdz mazin\u0101t ar diab\u0113tu saist\u012bt\u0101 metabolisk\u0101 stresa rad\u012btos boj\u0101jumus. <\/p>\n\n\n\n

Veicot t\u0101l\u0101ku anal\u012bzi, p\u0113tnieki var\u0113ja sniegt ieskatu par to, k\u0101p\u0113c psilocib\u012bnam var b\u016bt \u0161\u0101da aizsarg\u0101jo\u0161a iedarb\u012bba. IzmantojotWestern Blot<\/a>\" anal\u012bz\u0113 tika konstat\u0113ts, ka \u0101rst\u0113\u0161ana ar psilocib\u012bnu izrais\u012bja vair\u0101ku galveno apoptozes biomar\u0137ieru samazin\u0101\u0161anos \u03b2 \u0161\u016bn\u0101s, kas bija pak\u013cautas augsta glikozes un lip\u012bdu l\u012bme\u0146a iedarb\u012bbai, kas imit\u0113 diab\u0113tu. Apoptoze<\/a> (kas noz\u012bm\u0113 ieprogramm\u0113tu \u0161\u016bnu n\u0101vi) <\/em>ir galven\u0101 loma \u03b2 \u0161\u016bnu zudum\u0101 diab\u0113ta gad\u012bjum\u0101. Nov\u0113rot\u0101 psilocib\u012bna sp\u0113ja samazin\u0101t ar \u0161o procesu saist\u012btos mar\u0137ierus uzsver t\u0101 potenci\u0101lu gl\u0101bt \u03b2 \u0161\u016bnas diab\u0113ta gad\u012bjum\u0101. <\/p>\n\n\n\n

Rea\u0123\u0113jot uz savas komandas aizraujo\u0161ajiem atkl\u0101jumiem, Kova\u013c\u010duks atz\u012bm\u0113ja;<\/p>\n\n\n\n

\"M\u0113s negaid\u012bj\u0101m, ka psilocib\u012bns tik labi iedarbosies uz aizku\u0146\u0123a dziedzera \u0161\u016bn\u0101m.\" <\/em><\/p>\n\n\n\n

Vi\u0146\u0161 ar\u012b past\u0101st\u012bja PsyPost, ka;<\/p>\n\n\n\n

\"...mikrodoz\u0113\u0161ana ar burvju s\u0113n\u0113m, visticam\u0101k, pozit\u012bvi ietekm\u0113s cilv\u0113kus ar metabolisko sindromu (pirms diab\u0113ta) un diab\u0113tu,\".<\/em><\/p>\n\n\n\n

P\u0113t\u012bjuma ierobe\u017eojumi: S\u0101kotn\u0113jais posms<\/h4>\n\n\n\n

Lai gan tas ir daudzsolo\u0161s s\u0101kums \u0161aj\u0101 p\u0113tniec\u012bbas jom\u0101, p\u0113t\u012bjum\u0101 ir ierobe\u017eojumi, kas nor\u0101da uz nepiecie\u0161am\u012bbu p\u0113c turpm\u0101kiem p\u0113tniec\u012bbas projektiem. Visb\u016btisk\u0101kais, protams, ir tas, ka p\u0113t\u012bjums tika veikts, izmantojot \u017eurku insulinoma \u0161\u016bnu l\u012bniju, kas, lai gan ir piem\u0113rota \u013coti agr\u012bniem p\u0113t\u012bjumiem, nesp\u0113j piln\u012bb\u0101 atk\u0101rtot dz\u012bv\u0101 organisma sare\u017e\u0123\u012bt\u012bbu. <\/p>\n\n\n\n

Kova\u013cu\u010duks atz\u012bm\u0113ja; \"Mums \u0161is p\u0113t\u012bjums ir j\u0101veic ar dz\u012bvniekiem, lai p\u0101rliecin\u0101tos, ka tas darbojas tikpat labi k\u0101 in vitro,\". <\/em><\/p>\n\n\n\n

Turkl\u0101t \u0161aj\u0101 p\u0113t\u012bjum\u0101 tika apl\u016bkota tikai psilocib\u012bna iedarb\u012bba \u012bpa\u0161os stresa apst\u0101k\u013cos, ko izrais\u012bja augsts glikozes un lip\u012bdu l\u012bmenis. Tas atspogu\u013co tikai vienu no diab\u0113ta aspektiem, kas ir multifaktori\u0101la slim\u012bba, proti, tai rakstur\u012bgs pla\u0161s patolo\u0123iju kl\u0101sts, tostarp iekaisums, rezistence pret insul\u012bnu un 1. tipa diab\u0113ta gad\u012bjum\u0101 ar\u012b autoim\u016bn\u0101s sast\u0101vda\u013cas.<\/p>\n\n\n\n

\"\"<\/figure>\n\n\n\n

Revol\u016bcija diab\u0113ta \u0101rst\u0113\u0161an\u0101<\/h3>\n\n\n\n

\u0160is p\u0113t\u012bjums b\u016bt\u012bb\u0101 nor\u0101da uz iesp\u0113jamu revol\u016bciju diab\u0113ta \u0101rst\u0113\u0161an\u0101. Tas ir b\u016btiski, jo diab\u0113ts ir slim\u012bba, kas j\u0101\u0101rst\u0113 visas cilv\u0113ka dz\u012bves laik\u0101. Daudz\u0101s valst\u012bs cukura diab\u0113ta slimnieka vesel\u012bbas uztur\u0113\u0161anai nepiecie\u0161amie medikamenti ir d\u0101rgi, un cilv\u0113kiem ar zem\u0101kiem ien\u0101kumiem tie bie\u017ei vien tiek ziedoti p\u0101rtikas vai \u012bres maksas viet\u0101. K\u0101 saka Kolva\u010duk \"M\u0113s vienm\u0113r mekl\u0113jam dabisk\u0101kus\/tradicion\u0101l\u0101kus\/holistiskus slim\u012bbu \u0101rst\u0113\u0161anas veidus.\"<\/em><\/p>\n\n\n\n

Vai \u0161is p\u0113t\u012bjums var\u0113tu pav\u0113rt ce\u013cu n\u0101kotnei, kad cilv\u0113ki var\u0113s r\u016bp\u0113ties par savu vesel\u012bbu, izmantojot pieejamu un dab\u0101 sastopamu burvju trifeli?<\/strong><\/p>\n\n\n\n

L\u016bk, ceram! <\/strong>\ud83e\udd1e<\/p>\n\n\n\n

Piez\u012bme: Ja esat diab\u0113ta slimnieks, nep\u0101rtrauciet lietot medikamentus! \u0160is p\u0113t\u012bjums, lai gan aizraujo\u0161s, ir tikai s\u0101kuma stadij\u0101. Pirms dz\u012bvesveida mai\u0146as vienm\u0113r konsult\u0113jieties ar savu \u0101rstu.<\/em><\/p>","protected":false},"excerpt":{"rendered":"

Diabetes is a condition that currently affects 537 million people globally \u2014 and that number is only rising. With a prospective 783 million people on course to have diabetes by 2045, more effective and affordable treatments must be developed. A new study suggests microdosing psilocybin could play a part.\u00a0 In recent years,\u00a0psilocybin\u00a0(the psychoactive compound in […]<\/p>\n","protected":false},"author":11,"featured_media":10180,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[35],"tags":[],"class_list":["post-10177","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-science-and-studies"],"yoast_head":"\nScientists Say Microdosing Psilocybin May Treat Diabetes<\/title>\n<meta name=\"description\" content=\"It's an illness that affects 537 million people globally, but a new hope has emerged, scientists say microdosing psilocybin may treat diabetes.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.astrodose.eu\/lv\/zinatne-un-studijas\/zinatnieki-apgalvo-ka-psilocibina-mikrodozesana-var-arstet-diabetu\/\" \/>\n<meta property=\"og:locale\" content=\"lv_LV\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Scientists Say Microdosing Psilocybin May Treat Diabetes\" \/>\n<meta property=\"og:description\" content=\"It's an illness that affects 537 million people globally, but a new hope has emerged, scientists say microdosing psilocybin may treat diabetes.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.astrodose.eu\/lv\/zinatne-un-studijas\/zinatnieki-apgalvo-ka-psilocibina-mikrodozesana-var-arstet-diabetu\/\" \/>\n<meta property=\"og:site_name\" content=\"Astrodose - 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