{"id":10177,"date":"2024-05-24T22:37:23","date_gmt":"2024-05-24T20:37:23","guid":{"rendered":"https:\/\/www.astrodose.eu\/?p=10177"},"modified":"2024-05-24T22:38:38","modified_gmt":"2024-05-24T20:38:38","slug":"forskare-sager-att-mikrodosering-av-psilocybin-kan-behandla-diabetes","status":"publish","type":"post","link":"https:\/\/www.astrodose.eu\/sv\/science-and-studies\/scientists-say-microdosing-psilocybin-may-treat-diabetes\/","title":{"rendered":"Forskare s\u00e4ger att mikrodosering av Psilocybin kan behandla diabetes"},"content":{"rendered":"<p class=\"wp-block-paragraph\" style=\"font-size:21px\"><strong>Diabetes \u00e4r en sjukdom som f\u00f6r n\u00e4rvarande drabbar 537 miljoner m\u00e4nniskor i v\u00e4rlden - och den siffran bara \u00f6kar. Med en prognos p\u00e5 783 miljoner m\u00e4nniskor som kommer att ha diabetes \u00e5r 2045 m\u00e5ste mer effektiva och prisv\u00e4rda behandlingar utvecklas. En ny studie tyder p\u00e5 att mikrodosering av psilocybin kan spela en roll.\u00a0<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>P\u00e5 senare \u00e5r har psilocybin\u00a0<em>(den psykoaktiva f\u00f6reningen i magiska svampar och tryffel).\u00a0<\/em>har b\u00f6rjat uppm\u00e4rksammas f\u00f6r sin terapeutiska potential, s\u00e4rskilt f\u00f6r psykiska tillst\u00e5nd. Resultaten \u00e4r s\u00e5 lovande att det nu till och med studeras i samband med behandling av fysisk sm\u00e4rta, med framg\u00e5ngsrika resultat. Med s\u00e5 mycket av dess mekanismer fortfarande ett mysterium \u00e4r det inte konstigt att forskare inom alla discipliner \u00e4r angel\u00e4gna om att utforska ytterligare anv\u00e4ndningar av psilocybin.<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Detta \u00e5terspeglas i en&nbsp;<a href=\"https:\/\/www.mdpi.com\/2073-4425\/15\/2\/183\" target=\"_blank\" rel=\"noreferrer noopener\">ny sp\u00e4nnande studie<\/a>publicerad i tidskriften&nbsp;<em>Gener<\/em>, som unders\u00f6ker psilocybins genomf\u00f6rbarhet som en behandling f\u00f6r diabetes. Studief\u00f6rfattaren Igor Kovalchuk f\u00f6rklarade;<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><em>\"Diabetes och metabolt syndrom pl\u00e5gar samh\u00e4llet och vi letade efter olika s\u00e4tt att bidra till kampen mot dessa tillst\u00e5nd ... Eftersom mikrodosering med svamp kan bli ett av behandlingsalternativen f\u00f6r olika sjukdomar, ville vi testa om dess aktiva ingrediens, psilocybin, ocks\u00e5 skulle ha antidiabetiska effekter.\"<\/em><\/p>\n\n\n\n<figure class=\"wp-block-image size-large\"><img fetchpriority=\"high\" decoding=\"async\" width=\"1024\" height=\"432\" src=\"https:\/\/www.astrodose.eu\/wp-content\/uploads\/magic-truffles-swirl-background-1-1024x432.jpeg\" alt=\"\" class=\"wp-image-10178\" srcset=\"https:\/\/www.astrodose.eu\/wp-content\/uploads\/magic-truffles-swirl-background-1-1024x432.jpeg 1024w, https:\/\/www.astrodose.eu\/wp-content\/uploads\/magic-truffles-swirl-background-1-300x127.jpeg 300w, https:\/\/www.astrodose.eu\/wp-content\/uploads\/magic-truffles-swirl-background-1-768x324.jpeg 768w, https:\/\/www.astrodose.eu\/wp-content\/uploads\/magic-truffles-swirl-background-1-18x8.jpeg 18w, https:\/\/www.astrodose.eu\/wp-content\/uploads\/magic-truffles-swirl-background-1-600x253.jpeg 600w, https:\/\/www.astrodose.eu\/wp-content\/uploads\/magic-truffles-swirl-background-1.jpeg 1417w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h-psilocybin-the-serotonin-whisperer\">Psilocybin: Serotonin-viskaren<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Och det \u00e4r definitivt inte bara psykedelisk bandwagonhoppning. Psilocybin interagerar med serotoninreceptorerna i hj\u00e4rnan, vilket \u00e4r ett av de m\u00e5nga s\u00e4tten det \u00e4r effektivt som en <a href=\"https:\/\/www.astrodose.eu\/sv\/formaner\/tar-magiska-tryffel-mot-depression\/\" target=\"_blank\" rel=\"noreferrer noopener\">behandling av psykisk oh\u00e4lsa<\/a>. Men visste du att vi ocks\u00e5 har serotoninreceptorer i bukspottk\u00f6rteln, d\u00e4r insulin produceras? Med insulinproduktion\u00a0<em>(eller brist p\u00e5 s\u00e5dan)\u00a0<\/em>Eftersom psilocybin \u00e4r en av de viktigaste orsakerna till diabetes, kan psilocybins unika egenskaper f\u00f6r\u00e4ndra spelplanen?<\/p>\n\n\n\n<h3 class=\"wp-block-heading\" id=\"h-what-causes-diabetes\">Vad orsakar diabetes?<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">Diabetes \u00e4r en kronisk \u00e4mnesoms\u00e4ttningssjukdom som uppst\u00e5r n\u00e4r bukspottk\u00f6rteln slutar att producera insulin eller n\u00e4r kroppen inte l\u00e4ngre kan anv\u00e4nda det insulin som produceras p\u00e5 ett effektivt s\u00e4tt. Insulin \u00e4r det hormon som omvandlar glukos fr\u00e5n maten vi \u00e4ter till energi som v\u00e5ra celler kan anv\u00e4nda. N\u00e4r kroppen inte kan producera eller anv\u00e4nda insulin p\u00e5 ett effektivt s\u00e4tt leder det till h\u00f6ga glukosniv\u00e5er i blodet, vilket kallas&nbsp;<em>Hyperglykemi.&nbsp;<\/em>Med tiden kan dessa h\u00f6ga blodglukosniv\u00e5er skada kroppen och orsaka fel i olika organ och v\u00e4vnader. S\u00e5 enligt studief\u00f6rfattarna, genom att interagera med serotonincellerna i bukspottk\u00f6rteln, kan psilocybin kunna f\u00f6rhindra f\u00f6rlust av vitala insulinproducerande celler.&nbsp;<\/p>\n\n\n\n<figure class=\"wp-block-image is-resized\"><img decoding=\"async\" src=\"https:\/\/www.wholecelium.com\/wp-content\/uploads\/diabetes-shot.jpg\" alt=\"\" class=\"wp-image-188831\" style=\"width:840px;height:auto\"\/><figcaption class=\"wp-element-caption\"><em><mark style=\"background-color:rgba(0, 0, 0, 0)\" class=\"has-inline-color has-cyan-bluish-gray-color\">Foto av Matt C p\u00e5 Unsplash<\/mark><\/em><\/figcaption><\/figure>\n\n\n\n<h4 class=\"wp-block-heading\" id=\"h-how-the-study-worked\">Hur studien fungerade<\/h4>\n\n\n\n<p class=\"wp-block-paragraph\">I studien unders\u00f6kte forskarna effekterna av psilocybin p\u00e5 \u03b2-celler i bukspottk\u00f6rteln. Pankreatiska \u03b2-celler \u00e4r de celler som ansvarar f\u00f6r att producera insulin. N\u00e4r de \u00e4ventyras, till exempel hos en diabetiker, st\u00f6rs kroppens f\u00f6rm\u00e5ga att reglera blodsockerniv\u00e5n.&nbsp;<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Forskarna exponerade \u03b2-celler i bukspottk\u00f6rteln f\u00f6r h\u00f6g glukoshalt och h\u00f6g lipidhalt&nbsp;<em>(fett)&nbsp;<\/em>ett tillst\u00e5nd som \u00e5terspeglar den metaboliska stress som diabetes orsakar. De anv\u00e4nde sig av en&nbsp;<a href=\"https:\/\/www.sigmaaldrich.com\/NL\/en\/product\/mm\/scc208\" target=\"_blank\" rel=\"noreferrer noopener\">Insulinomcellinje fr\u00e5n r\u00e5tta<\/a>, en vetenskaplig modell som anv\u00e4nds p\u00e5 grund av dess relevans f\u00f6r m\u00e4nskliga \u03b2-cellers funktion.&nbsp;<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Efter att ha odlats i ett n\u00e4ringsrikt medium behandlades n\u00e5gra av cellerna med en specifik koncentration av psilocybin. Efter psilocybinbehandlingen s\u00e4nktes cellerna ned i f\u00f6rh\u00e5llanden med h\u00f6g glukos- och lipidhalt, ber\u00e4knade f\u00f6r att framkalla den p\u00e5frestning och skada som allm\u00e4nt observeras i \u03b2-cellerna i bukspottk\u00f6rteln hos personer med diabetes.&nbsp;<\/p>\n\n\n\n<figure class=\"wp-block-image is-resized\"><img decoding=\"async\" src=\"https:\/\/www.wholecelium.com\/wp-content\/uploads\/science-research-test-tube.jpg\" alt=\"\" class=\"wp-image-188832\" style=\"width:840px;height:auto\"\/><figcaption class=\"wp-element-caption\"><em><mark style=\"background-color:rgba(0, 0, 0, 0)\" class=\"has-inline-color has-cyan-bluish-gray-color\">Foto av Julia Koblitz p\u00e5 Unsplash<\/mark><\/em><\/figcaption><\/figure>\n\n\n\n<h3 class=\"wp-block-heading\" id=\"h-psilocybin-protects-cells\">Psilocybin skyddar cellerna<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">Forskarna observerade att de celler som hade behandlats med psilocybin visade betydligt b\u00e4ttre viabilitet j\u00e4mf\u00f6rt med dem som inte hade behandlats med psilocybin. Detta resultat tyder p\u00e5 att psilocybin har en skyddande effekt p\u00e5 pankreatiska \u03b2-celler, vilket bidrar till att lindra skadorna av den metaboliska stress som \u00e4r f\u00f6rknippad med diabetes.&nbsp;<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Vid ytterligare analys kunde forskarna ge insikter i varf\u00f6r psilocybin kan ha dessa skyddande effekter. Med hj\u00e4lp av '<a href=\"https:\/\/en.wikipedia.org\/wiki\/Western_blot\" target=\"_blank\" rel=\"noreferrer noopener\">Western Blot<\/a>I sin analys fann studien att psilocybinbehandling ledde till en minskning av flera viktiga apoptotiska biomark\u00f6rer i \u03b2-celler som hade utsatts f\u00f6r de h\u00f6ga glukos-, h\u00f6ga lipidniv\u00e5erna som efterliknar diabetes.&nbsp;<a href=\"https:\/\/en.wikipedia.org\/wiki\/Apoptosis\" target=\"_blank\" rel=\"noreferrer noopener\">Apoptos<\/a>&nbsp;<em>(vilket betyder programmerad celld\u00f6d)&nbsp;<\/em>spelar en nyckelroll i f\u00f6rlusten av \u03b2-celler vid diabetes. Den observerade f\u00f6rm\u00e5gan hos psilocybin att minska mark\u00f6rer associerade med denna process belyser dess potential att r\u00e4dda \u03b2-celler under diabetiska f\u00f6rh\u00e5llanden.&nbsp;<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Som svar p\u00e5 sitt lags sp\u00e4nnande resultat kommenterade Kovalchuk;<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><em>\"Vi f\u00f6rv\u00e4ntade oss inte att psilocybin skulle fungera s\u00e5 bra p\u00e5 bukspottk\u00f6rtelceller,\"&nbsp;<\/em><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Han ber\u00e4ttade ocks\u00e5 f\u00f6r PsyPost att;<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><em>\"... mikrodosering med magiska svampar kommer sannolikt att ha en positiv effekt f\u00f6r personer med metaboliskt syndrom (pre-diabetes) och diabetes,\"<\/em><\/p>\n\n\n\n<h4 class=\"wp-block-heading\" id=\"h-study-limitations-early-days\">Begr\u00e4nsningar i studien: Tidiga dagar<\/h4>\n\n\n\n<p class=\"wp-block-paragraph\">\u00c4ven om det \u00e4r en lovande start inom detta forskningsomr\u00e5de finns det begr\u00e4nsningar i studien som visar p\u00e5 behovet av ytterligare forskningsprojekt. Det mest anm\u00e4rkningsv\u00e4rda var naturligtvis att studien genomf\u00f6rdes med hj\u00e4lp av en insulinomcellinje fr\u00e5n r\u00e5tta, som visserligen \u00e4r l\u00e4mplig f\u00f6r mycket tidiga unders\u00f6kningar, men som inte helt kan \u00e5terskapa komplexiteten hos en levande organism.&nbsp;<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Kovaluchuk noterade;&nbsp;<em>\"Vi m\u00e5ste utf\u00f6ra den h\u00e4r studien p\u00e5 djur f\u00f6r att vara s\u00e4kra p\u00e5 att den fungerar lika bra som in vitro\", s\u00e4ger han.&nbsp;<\/em><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Dessutom tittade denna studie bara p\u00e5 effekterna av psilocybin under specifika f\u00f6rh\u00e5llanden av stress inducerad av h\u00f6g glukos och h\u00f6ga lipidf\u00f6rh\u00e5llanden. Detta representerar bara en aspekt av diabetes, som \u00e4r en multifaktoriell sjukdom, vilket inneb\u00e4r att den uppvisar ett brett spektrum av patologier inklusive inflammation, insulinresistens och i fallet med typ 1-diabetes, autoimmuna komponenter.<\/p>\n\n\n\n<figure class=\"wp-block-image\"><img decoding=\"async\" src=\"https:\/\/www.wholecelium.com\/wp-content\/uploads\/astrodose-microdosing-psilocybin-strip-17.png\" alt=\"\" class=\"wp-image-188833\"\/><\/figure>\n\n\n\n<h3 class=\"wp-block-heading\" id=\"h-a-revolution-in-diabetes-treatment\">En revolution inom diabetesbehandling<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">I grund och botten pekar denna studie mot en potentiell revolution i behandlingen av diabetes. Detta \u00e4r viktigt eftersom det \u00e4r ett tillst\u00e5nd som m\u00e5ste hanteras under hela livet. I m\u00e5nga l\u00e4nder \u00e4r de mediciner som kr\u00e4vs f\u00f6r att uppr\u00e4tth\u00e5lla h\u00e4lsan hos en diabetiker dyra, och f\u00f6r dem med l\u00e4gre inkomster offras de ofta i st\u00e4llet f\u00f6r mat eller hyra. Som Kolvachuk s\u00e4ger&nbsp;<em>\"Vi letar alltid efter mer naturliga\/traditionella\/holistiska s\u00e4tt att behandla sjukdomar.\"<\/em><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Kan denna forskning bana v\u00e4g f\u00f6r en framtid d\u00e4r m\u00e4nniskor kan sk\u00f6ta sin h\u00e4lsa med hj\u00e4lp av den prisv\u00e4rda och naturligt f\u00f6rekommande magiska tryffeln?<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Nu hoppas vi!&nbsp;<\/strong>\ud83e\udd1e<\/p>\n\n\n\n<p class=\"wp-block-paragraph\" style=\"font-size:11px\"><em>Obs: Om du \u00e4r diabetiker, sluta inte ta dina mediciner! Denna forskning, \u00e4ven om den \u00e4r sp\u00e4nnande, \u00e4r i sin linda. R\u00e5dg\u00f6r alltid med din l\u00e4kare innan du g\u00f6r en livsstilsf\u00f6r\u00e4ndring.<\/em><\/p>","protected":false},"excerpt":{"rendered":"<p>Diabetes is a condition that currently affects 537 million people globally \u2014 and that number is only rising. With a prospective 783 million people on course to have diabetes by 2045, more effective and affordable treatments must be developed. A new study suggests microdosing psilocybin could play a part.\u00a0 In recent years,\u00a0psilocybin\u00a0(the psychoactive compound in [&hellip;]<\/p>\n","protected":false},"author":11,"featured_media":10180,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[35],"tags":[],"class_list":["post-10177","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-science-and-studies"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.6 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Scientists Say Microdosing Psilocybin May Treat Diabetes<\/title>\n<meta name=\"description\" content=\"It&#039;s an illness that affects 537 million people globally, but a new hope has emerged, scientists say microdosing psilocybin may treat diabetes.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.astrodose.eu\/sv\/vetenskap-och-studier\/forskare-sager-att-mikrodosering-av-psilocybin-kan-behandla-diabetes\/\" \/>\n<meta property=\"og:locale\" content=\"sv_SE\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Scientists Say Microdosing Psilocybin May Treat Diabetes\" \/>\n<meta property=\"og:description\" content=\"It&#039;s an illness that affects 537 million people globally, but a new hope has emerged, scientists say microdosing psilocybin may treat diabetes.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.astrodose.eu\/sv\/vetenskap-och-studier\/forskare-sager-att-mikrodosering-av-psilocybin-kan-behandla-diabetes\/\" \/>\n<meta property=\"og:site_name\" content=\"Astrodose - 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